Risk Assessment Approaches for Carcinogenic Food Contaminants

Models for carcinogenic risk assessment.

approach is the recognition that the response to a carcinogenic agent depends on the rate of exposure. For the radioactive agents the priority for the study of the so-called dose-rate effects appears to belong to Upton (3). A review (4) indicates that important dose-rate effects exist also for certain chemical carcinogens. Another item that I miss in Comnfield's approach is the phenomenon of sy...

Models for carcinogenic risk assessment.

Risk ranking priority of carcinogenic and/or genotoxic environmental contaminants in food in Belgium.

This paper focuses on the risks of environmental carcinogenic and/or genotoxic contaminants in food. It describes, for each contaminant studied, the carcinogenicity and genotoxicity, the toxicological reference values, the exposure and the risk characterisation. The compounds studied were classified into 3 categories based on a risk assessment. Effects others than carcinogenicity and/or genotox...

Statistical issues in carcinogenic risk assessment.

Considerable progress has been made on the development of a variety of analytical methods to aid in the carcinogenic risk associated with exposure to both occupational and environmental agents. Although the development of these methods has been accompanied by consideration of many statistical issues, there are many areas where additional effort could be directed if these analytical methods are ...

Approaches to Monitoring Organic Environmental Contaminants in Food

Trace quantities of potentially toxic organic compounds are frequently found in the environment. These compounds sometimes possess properties that may have teratogenic, mutagenic, and even carcinogenic effects on humans and animals. Some of the compounds, such as pesticides, have been intentionally released into the environment (1), while others have found their way into the environment by acci...